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Although the amygdala complex has long been known to exert a profound influence on cardiovascular activity, the neuronal and connectional substrate mediating these influences remains unclear. This paper describes a direct amygdaloid projection to medullary sensory and motor structures involved in cardiovascular regulation, the nucleus of the solitary tract(More)
Uptake, replication, and transneuronal passage of a swine neurotropic herpesvirus (pseudorabies virus, PRV) was evaluated in the rat CNS. PRV was localized in neural circuits innervating the tongue, stomach, esophagus and eye with light microscopic immunohistochemistry. In each instance, the distribution of PRV-immunoreactive neurons was entirely consistent(More)
The general objectives of our research, presented in this series of papers, were to develop a computational model of the brain stem respiratory neural network and to explore possible neural mechanisms that provide the genesis of respiratory oscillations and the specific firing patterns of respiratory neurons. The present paper describes models of single(More)
Using the fluorescent dye, double retrograde-labeling tracing technique, separate populations of insular cortex neurons were demonstrated to project to the amygdaloid central nucleus and to autonomic nuclei of the dorsal medulla. Both populations were located in layer V of the agranular and granular insula with neurons projecting to the dorsal medulla(More)
We have used confocal microscopy to analyze the vagal afferent innervation of the rat heart. Afferents were labeled by injecting 1,1'-dioleyl-3,3,3',3'-tetramethylindocarbocyanine methanesulfonate (DiI) into the nodose ganglia of animals with prior supranodose de-efferentations, autonomic ganglia were stained with Fluoro-gold, and tissues were examined in(More)
1. We explore the roles of conductances in Hodgkin-Huxley (HH) models using a method that allows the explicit linking of HH model input-output behavior to parameter values for maximal conductances, voltage shifts, and time constants. The procedure can be used to identify not only the parameter values most critical to supporting a neuronal activity pattern(More)
We defined the central circuit innervating various regions of the rat heart using a neurotropic herpesvirus as a transneuronal tracer. Location of viral antigens in the brain after cardiac injection of three strains of pseudorabies virus (PRV) provided insight into vagal preganglionic neurons and their connected interneurons. At short survival times,(More)
Previous light microscopic work in the rat has demonstrated that many dendrites of vagal gastric motoneurons extend beyond the cytoarchitectural boundaries of the dorsal motor nucleus of the vagus (DMV) into the nucleus of the solitary tract (NST), where they overlap with the central terminal field of vagal gastric primary sensory neurons (Shapiro and(More)
The study constructs computational models of neurons in order to examine the contribution that their response dynamics may make to functional properties at the system level. As described in the accompanying study, neurons in the cardiorespiratory nucleus tractus solitarii (NTS) of the rat were recorded in vitro. When these cells were intracellularly(More)
1. Electrical stimulation of the central nucleus of the amygdala in the urethane or alpha-chloralose anaesthetized rabbit evokes a bradycardia with a rapid onset and a concomitant fall in arterial blood pressure. 2. Extracellular neuronal activity was recorded in the ipsilateral nucleus tractus solitarius and dorsal vagal nucleus whilst stimulating the(More)