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Niemarm-Pick disease type C (NPD-C) is a heterogeneous group of neurovisceral storage disorders characterized by abnormal intralysosomal accumulation of cholesterol and sphingomyelin in histiocyte-like foam cells throughout the reticuloendothelial system, brain, and other organs associated with a secondary deficiency of cholesterol esterification (Pentchev(More)
OBJECTIVES Osteoarthritis (OA) is the most common form of arthritis, affecting approximately 15% of the human population. Recently, increased concentration of nitric oxide in serum and synovial fluid in patients with OA has been observed. However, the exact role of nitric oxide in the initiation of OA has not been elucidated. The aim of the present study(More)
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