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Based on the Suzuki product-formula approach, we construct a family of unconditionally stable algorithms to solve the time-dependent Maxwell equations. We describe a practical implementation of these algorithms for one-, two-, and three-dimensional systems with spatially varying permittivity and permeability. The salient features of the algorithms are(More)
Morphological image analysis is applied to the time evolution of the probability distribution of a quantum particle moving in two- and three-dimensional billiards. It is shown that the time-averaged Euler characteristic of the probability distribution provides a well defined quantity to distinguish between classically integrable and nonintegrable billiards.(More)
We present a family of unconditionally stable algorithms, based on the Suzuki product-formula approach, that solve the time-dependent Maxwell equations in systems with spatially varying permit-tivity and permeability. Salient features of these algorithms are illustrated by computing the density of states and by simulating the propagation of light in a(More)
Vascular homoeostasis, development and disease critically depend on the regulation of endothelial cell-cell junctions. Here we uncover a new role for the F-BAR protein pacsin2 in the control of VE-cadherin-based endothelial adhesion. Pacsin2 concentrates at focal adherens junctions (FAJs) that are experiencing unbalanced actomyosin-based pulling. FAJs move(More)
PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib (BTZ) in leukemic cells in vitro. We here undertook a multi-modality (DNA, mRNA, miRNA) array-based analysis of human CCRF-CEM leukemia cells and BTZ-resistant subclones to determine whether or not(More)
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