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Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes
Valproate (VPA), one of the mood stabilizers and antiepileptic drugs, was recently found to inhibit histone deacetylases (HDAC). Increasing reports demonstrate that VPA has neurotrophic effects in… Expand
Chronic microglial activation and progressive dopaminergic neurotoxicity.
PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident… Expand
Placental deposition of C-reactive protein is a common feature of human pregnancy.
This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP… Expand
Effect of a bone marrow microenvironment on the ex‐vivo expansion of umbilical cord blood progenitor cells
- I. Galán, J. A. Deleón, +4 authors J. Santolaya-Forgas
- International journal of laboratory hematology
- 1 February 2007
Progenitor cells (CD34+) can be isolated from umbilical cord blood and used to correct or reconstitute various cell lines within the haematopoietic and endothelial cell lineage. The main disadvantage… Expand