J. S. Gehring

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Tiling microarrays have become an important platform for the investigation of regulation in expression, DNA modification, and DNA-protein interaction. Since unbiased in relation to annotation they provide an powerful tool for biological research. Beside the analysis of single conditions, the investigation of regulation between multiple experimental(More)
UNLABELLED High-throughput sequencing has become an essential experimental approach for the investigation of transcriptional mechanisms. For some applications like ChIP-seq, several approaches for the prediction of peak locations exist. However, these methods are not designed for the identification of transcription start sites (TSSs) because such datasets(More)
The GSRI package estimates the number of significantly regulated genes in gene sets, assessing their differential effects between groups through statistical testing. The approach is based on the fact that p-values of a statistical test are uniformly distributed under the null hypothesis and shifted towards small values in the case of its violation. The(More)
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