Evolution of the human heart has incorporated a variety of successful strategies for motion used throughout the animal kingdom. One such strategy is to add the efficiency of torsion to compression so that blood is wrung, as well as pumped, out of the heart. Models of cardiac torsion have assumed uniform contractile properties of muscle fibers throughout the… (More)
Stretch induces changes in cardiomyocyte biology that are implicated in heart failure, but the mechanism by which stretch is sensed and signals are transduced is unknown. New understanding of the Z disc elements of contractile units are beginning to elucidate the mechanism of stretch sensing and its relation to cardiac adaptation and disease.
Emerging AI techniques will make possible new intelligent help features, such as 'active help' (interrupting the user when appropriate) and 'back channel' communication (allowing users to send a message to a help system). An investigation was conducted to determine whether these features would be useful. In the experiment, users of a job scheduling… (More)
Tension generation can be studied by applying step perturbations to contracting muscle fibers and subdividing the mechanical response into exponential phases. The de novo tension-generating isomerization is associated with one of these phases. Earlier work has shown that a temperature jump perturbs the equilibrium constant directly to increase tension.… (More)
A multipurpose digital test core utilizing programmable logic has been introduced [1,2] to implement many of the functions of traditional automated test equipment (ATE). While previous papers have described the theory, this paper quantifies the results and presents additional applications with improved methods operating up to 4.4Gpbs. The digital test core… (More)
Subunit exchange between groups of myosin filaments at equilibrium in a volume similar to a sarcomere is simulated using Monte Carlo (probabilistic) methods. Five published kinetic parameters (three rate constants and two cooperativity parameters) which govern the assembly of thick filaments from purified myosin at pH 8.0 are used for the computations.… (More)
A multipurpose digital test core utilizing programmable logic has been introduced [1,2] to implement many of the functions of traditional automated test equipment (ATE). While previous papers have described the theory, this paper quantifies the results and presents additional applications with improved methods. The digital test core provides a substantial… (More)
Measured in this study was the effectiveness of two types of retrofits in mitigating shocks in tennis rackets with ideally high grip fixity. The retrofits were a cushioned grip tape and a string implant device. Three types of rackets were investigated: wood, graphite composite, and metal. For low speed ball impact, neither retrofit changed significantly the… (More)