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Escherichia coli fed-batch cultivations at 22 m3 scale were compared to corresponding laboratory scale processes and cultivations using a scale-down reactor furnished with a high-glucose concentration zone to mimic the conditions in a feed zone of the large bioreactor. Formate accumulated in the large reactor, indicating the existence of oxygen limitation(More)
The exact role of fluid mechanics in the patho-physiological process of atherosclerosis has been a research topic over many years, yet without clear conclusive result. One has observed that morphological manifestations of the disease are found at some well-defined locations: certain vessel bifurcations and in curvatures. The flow in these regions is(More)
Cardiac MR group Lund, Dept. of Clinical Physiology, Lund University, Lund, Sweden Full list of author information is available at the end of the article Figure 1 Design and construction of the vortex ring flow phantom. a) 2D view of the flow rectifier and vortex ring tank. All measures are in millimeters (mm). b) 3D view of the flow rectifier and vortex(More)
Background Computational Fluid Dynamics (CFD) can be utilized to evaluate hemodynamic characteristics in patients with surgically implemented Total Cavo Pulmonary Connection (TCPC). The simulation process is however often complex and rarely takes into account characteristics such as pulmonary resistance and Aorto-Pulmonary Collaterals in analyses to predict(More)
Background 4D phase contrast magnetic resonance blood flow measurements (4D PC-MR) is a promising tool for clinical assessment of cardiac function, but lack of independent validation may limit clinical adoption. Previous validation studies are limited by lack of pulsatility [1,2] or by the need of a post hoc correction factor to compensate for differences(More)
PURPOSE Patients with complex congenital heart disease may need to be converted to a Fontan circulation with systemic venous return surgically connected to the pulmonary circulation. These patients frequently form aortopulmonary collaterals (APC), that is arterial inflows to the pulmonary artery vascular tree. The aim of this study was to develop a method(More)
PURPOSE This study aimed to: (i) present and characterize a phantom setup for validation of four-dimensional (4D) flow using particle imaging velocimetry (PIV) and planar laser-induced fluorescence (PLIF); (ii) validate 4D flow velocity measurements using PIV; and (iii) validate 4D flow vortex ring volume (VV) using PLIF. METHODS A pulsatile pump and a(More)
The aim of this study was to evaluate the accuracy of maximum velocity measurements using volumetric phase-contrast imaging with spiral readouts in a stenotic flow phantom. In a phantom model, maximum velocity, flow, pressure gradient, and streamline visualizations were evaluated using volumetric phase-contrast magnetic resonance imaging (MRI) with velocity(More)
This Master Thesis in Technical Mathematics at LTH, directed towards simulation and computation, has treated the subject of fluid-structure interaction (FSI) for incompressible flow with small vibrations. The open source packages DEAL.II and OpenFOAM have been used to create a coupling between a finite element formulation for structure and a finite volume(More)