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BACKGROUND Many patients discontinue antidepressant therapy long before the six-month minimum duration recommended for the treatment of major depression and many other diagnoses. PURPOSE To estimate the duration of antidepressant treatment and to analyse the following factors in relation to treatment adherence: age, sex, polypharmacy and type of drug. (More)
Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the cortico-striatal pathway and significantly affect the quality of life of the patients, but this has not been a therapeutic focus in HD to date. We postulated that adenosine A(2A) receptors (A(2A)R), located at pre- and post-synaptic elements of the cortico-striatal(More)
Parkinson's disease (PD) is characterized by motor dysfunction associated with dopaminergic degeneration in the dorsolateral striatum (DLS). However, motor symptoms in PD are often preceded by short-term memory deficits, which have been argued to involve deregulation of medial prefrontal cortex (mPFC). We now used a 6-hydroxydopamine (6-OHDA) rat PD model(More)
Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processes occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. However, the exact mechanisms(More)
  • T Caraballo, J Real, L Shaikhet
  • 2007
The investigation of stability for hereditary systems is often related to the construction of Lyapunov func-tionals. The general method of Lyapunov functionals construction which was proposed by V. Kolmanovskii and L. Shaikhet and successfully used already for functional differential equations, for difference equations with discrete time, for difference(More)
BACKGROUND Raised rates of psychoses among ethnic minorities have been reported. Exposure to antipsychotic medications can give information on mental illness management and ethnic-related differences. OBJECTIVE To compare exposure to antipsychotic medications in immigrant and native-born populations in Spain. METHOD Descriptive cross-sectional study of(More)
Lecture topics in Computer Organization courses offered by different Universities around the world do not differ significantly. This is because, in general, lecturers use the same textbooks and are inspired by common curriculum sources. However, lab courses and project assignments require more and more expensive resources (computers, assemblers or assembler(More)
BACKGROUND There is evidence supporting the effectiveness of psychoeducation (PE) in patients with symptoms of depression in primary care (PC), but very few studies have assessed this intervention in antidepressant-naïve patients. The aim of this study is to assess the effectiveness of a PE program in these patients, since the use of antidepressant (AD)(More)
INTRODUCTION Recent studies suggest that the ADHD subtypes would be best conceptualized as separate clinical entities, based on their epidemiology, central and associate symptomatology. OBJECTIVES To determine the differences and similarities between subtypes in its associate symptomatology, specifically in the neuropsychological phenotype of executive(More)
GPR37 is an orphan G protein-coupled receptor highly expressed in the brain. The precise function of GPR37 is still unknown, but a number of evidences indicate it modulates the dopaminergic system. Here, we aimed to determine the role of GPR37 on the control of cocaine-mediated electrophysiological effects (synaptic transmission and short-term plasticity)(More)