J. R. de Miguel

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The isolation and purification of the peptides containing the hormonogenic tyrosyl residues in thyroglobulin is of great interest to the understanding of structure-function relationships in this iodoprotein. This is usually performed in reduced alkylated selectively hydrolyzed thyroglobulin by subsequent HPLC fractionation. However, the main difficulty(More)
We analyze various models introduced in social choice to aggregate individual preferences. We show that on the basis of most of these models there is a system of functional equations such that, in many cases, the origin of impossibility results in a social choice model is the non-existence of a solution for the corresponding system. Among the functional(More)
Falcipain-2 and falcipain-3 are papain-family cysteine proteases of the malaria parasite Plasmodium falciparum that are responsible for host hemoglobin hydrolysis to provide amino acids for parasite protein synthesis. Different heteroarylnitrile derivatives were studied as potential falcipain inhibitors and therefore potential antiparasitic lead compounds,(More)
The surgical treatment of all types of scoliosis pursues correction of the deformity, get a solid spinal fusion and balance the trunk in the sagittal and coronal plane. For this it is necessary to perform technically demanding surgery, long lasting, with great exposure of the surgical field, high blood loss and ultimately extremely aggressive. No doubt we(More)
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