Learn More
Brain aging is associated with altered Ca(2+) regulation. However, many Ca(2+) signal transduction mechanisms have not been explored in the aged brain. Here, we report that cytosolic expression and activity of the Ca(2+)-dependent protein phosphatase calcineurin (CaN) increases in the hippocampus during aging. CaN changes were paralleled by increased(More)
The current study examined effects of chronic estradiol replacement on cognition and biomarkers of aging. Young, middle-aged, and aged rats were ovariectomized and implanted with blank capsules, or capsules containing high or low doses of estradiol benzoate (EB). Three weeks later, animals were tested on inhibitory avoidance and cue and spatial(More)
Brain aging is associated with altered Ca regulation. However, many Ca signal transduction mechanisms have not been explored in the aged brain. Here, we report that cytosolic expression and activity of the Ca-dependent protein phosphatase calcineurin (CaN) increases in the hippocampus during aging. CaN changes were paralleled by increased activation, but(More)
Dynorphins, endogenous kappa-opioid agonists widely expressed in the central nervous system, have been reported to increase following diverse pathophysiological processes, including excitotoxicity, chronic inflammation, and traumatic injury. These peptides have been implicated in cognitive impairment, especially that associated with aging. To determine(More)
S. Winograd's papers "On computing the discrete Fourier transform" (1976 and 1978) allow one to know the minimum number of multiplications to compute a DFT if the length is a power of a prime and to build such algorithms for small lengths. It is suggested that longer transforms be 'built up' with the short algorithms. For this Winograd proposes and Kolba &(More)
  • 1