J R Hovious

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Chronic treatment of female Sprague-Dawley rats with methadone 5 mg/kg IP throughout gestation and lactation resulted in an increased oral self-administration (S.A.) of morphine by their 85-90-day-old offspring. By day 16 of the S.A. treatment schedule methadone offspring were taking 75 to 80% of their total fluid intake as morphine solution when given a(More)
The purpose of this study was to determine the effect that chronic maternal exposure to narcotics has on the effectiveness of analgesic drugs in the offspring. No exposure related differences were observed in the base level response to the noxious stimuli used. However, offspring of methadone and morphine-treated mothers tended to show decreased response(More)
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