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Water accumulation in the heart is important in ischemia-reperfusion injury and operations performed by using cardiopulmonary bypass, with cardiac dysfunction associated with myocardial edema being the principal determinant of clinical outcome. As an initial step in determining the role of aquaporin (AQP) water channels in myocardial edema, we have assessed(More)
There has been tremendous progress in reducing disability and death from ACS. But many patients still die before reaching the hospital because patients and family members fail to recognize the signs of ACS and fail to activate the EMS system. Once the patient with ACS contacts the healthcare system, providers must focus on support of cardiorespiratory(More)
We tested the hypothesis that sensitization to heroin enhances appetitive motivational processes involving food reward. In Experiment 1, sixteen rats were exposed to positive pairings of a light stimulus and food for 4 consecutive daily sessions. Then, the rats received either saline or heroin (2 mg/kg) injections before placement in activity monitors for 9(More)
OBJECTIVE To document the adult adjustment of survivors of childhood institutional abuse. METHOD Two hundred and forty-seven adult survivors of institutional abuse with a mean age of 60 were interviewed with a protocol that included the Childhood Trauma Questionnaire, modules from the Structured Clinical Interview for Axis I Disorders of DSM IV and the(More)
To review the use of recombinant activated factor VII in paediatric cardiac surgery. Retrospective chart review. Paediatric intensive care unit in a stand-alone university-affiliated children’s hospital. Cardiac surgical patients who received recombinant activated factor VII (rFVIIa, NovoSeven; NovoNordisk, Copenhagen, Denmark) between June 2002 and June(More)
To compare clinical assessment of cardiac performance with an invasive method of haemodynamic monitoring. Prospective observational study in a 16-bed tertiary paediatric intensive care unit. Infants and children undergoing cardiopulmonary bypass and surgical repair of congenital heart lesions. Based on physical examination and routinely available(More)
To redress the paucity of studies evaluating non-invasive respiratory support in bronchiolitis patients. Following ethics committee approval, the clinical database of a tertiary 23-bed paediatric intensive care unit (PICU) was reviewed for bronchiolitis admissions from January 2000 to December 2009. Length of stay (LOS), ventilatory requirements and risk(More)
Cardiomyopathy contributes to morbidity and mortality in Duchenne muscular dystrophy (DMD), a progressive muscle-wasting disorder. A major feature of the hearts of DMD patients and the mdx mouse model of the disease is cardiac fibrosis. Connective tissue growth factor (CTGF) is involved in the fibrotic process in many organs. This study utilized the mdx(More)
Transmembrane water transport is mediated by aquaporins (AQPs), of which AQP1 and AQP4 are expressed in skeletal muscle. AQP4 expression is reduced in Duchenne muscular dystrophy (DMD) patients, and is reported to correlate with decreased α1-syntrophin and altered osmotic permeability. In this study, we assessed the relationship between AQP1, AQP4,(More)
A more restricted definition of a PLA folding is introduced, which is called bipartite folding. The additional constraints of a bipartite folding force the resulting PLA to have a more uniform structure. This structure of a column bipartite folding is then exploited when subsequently folding the rows of the PLA. A column bipartite folding creates fewer(More)