J. R. Bedwani

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The release of [3H]GABA from superfused slices of rat cerebral cortex was investigated in the presence and absence of the GABA-transaminase inhibitor aminooxyacetic acid (AOAA). In the latter case, an ion-exchange column chromatographic technique was used to separate [3H]GABA from tritiated metabolites released with it into the superfusate. In the absence(More)
The release of [3H]gamma-aminobutyric acid (GABA) from pre-loaded slices of rat cerebral cortex was investigated in the presence and absence of the GABA-transaminase inhibitors gabaculine and gamma-vinyl GABA. In the experiments carried out without an inhibitor, an ion-exchange column chromatographic technique was used to separate [3H]GABA from tritiated(More)
1. The output of prostaglandins from the spleens of cats and dogs was studied. Comparison is made between the results found in the two species. 2. The release of prostaglandins was investigated in isolated saline-perfused spleens and in incubates of spleen slices. Release in response to nerve stimulation, and exposure to adrenaline or noradrenaline was(More)
OBJECTIVE To compare the mechanical properties of fullthickness bladder strips from poorly compliant neuropathic bladders with controls and to determine the overall contribution that mechanical factors might have in the aetiology of the poor compliance of medium-fill cystometry. PATIENTS AND METHODS The visco-elastic properties of full-thickness bladder(More)
OBJECTIVES To confirm the existence of relaxation responses to electrical-field stimulation in strips of human detrusor, and to compare these responses in strips from control subjects with those in strips from a group of neuropathic patients exhibiting hyperreflexia. PATIENTS AND METHODS Detrusor specimens were obtained at operation from a group of(More)
The in vitro responses of isolated detrusor strips obtained from neuropathic patients with neuropathic bladder dysfunction were found to be supersensitive to both carbachol [ED50 1.2 x 10(-6) M. versus 2.5 x 10(-6) M. in control strips; p < 0.005] and potassium chloride [ED50 41.8 mM. versus 49.3 mM. in control strips, p < 0.05]. There were no significant(More)
1. The inactivation of prostaglandin E2 by the rabbit lung was estimated in vivo by comparing its depressor potency following intravenous and intra-aortic injections, and in vitro by measuring the rate of disappearance of smooth muscle stimulating activity when the prostaglandin was incubated with high speed supernatant fractions from lung homogenates. 2.(More)
Prostaglandins of the E series (PGE) have been shown to be potent nasal vasoconstrictors but have not previously been isolated from the nasal mucosa. Here we report the isolation of a biologically active substance with properties similar to PGE from pig nasal mucosa. The substance was identified as PGE on the following criteria: 1 our isolation procedure(More)