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The glycoprotein corticosteroid-binding globulin (CBG) migrates as doublet bands in PAGE and SDS-PAGE, and as numerous bands in isoelectric focusing (IEF). This study deals with the origin of this heterogeneity. Desialation of rat CBG with neuraminidase does not abolish the doublet in either PAGE or SDS-PAGE, indicating that the doublet does not arise as a(More)
An evaluation of a number of non-invasive physiological measures of stress was conducted, using bank employees attending a two-week residential course. The stressor involved was the preparation and delivery of a 15-min public lecture. The physiological parameters measured were urinary excretion rates of noradrenaline (NA), adrenaline (A), dopamine and(More)
The effects of a single intraperitoneal injection of nicotine hydrogen tartrate (200 micrograms/kg) on the plasma levels of thyroxine, triiodothyronine and corticosterone were monitored over a 24 hour period. Nicotine did not alter the plasma levels of either of the thyroid hormones but did produce a significant increase in plasma corticosterone, an effect(More)
Plasma ACTH and corticosterone profiles were measured following the intraperitoneal injection of nicotine or ACTH, or following exposure of rats to unpredictable stress. The elevation in plasma corticosterone was biphasic in nature in all cases, whereas plasma ACTH levels demonstrated only a single peak which rapidly declined to a sustained plateau level.(More)
Twelve experienced and seven naive male subjects with a similar Vo2max, performed an incremental work test on an electronically braked bicycle until exhaustion. High venous lactate concentrations were recorded in both groups (naive-11.74 +/- 2.43, experienced-13.96 +/- 2.36 mmol/liter). No significant relationship could be demonstrated between Vo2max,(More)
Prolonged exposure of male C. S. F. rats to irregular signalled footshick from which they could escape for up to 71 days produced profound morphological changes. Retardation in growth, adrenal hypertrophy associated with an increase in the zona fasiculata a-nd zona reticularis, and changes in the microcirculation of the heart were observed. There was a(More)
Nicotine was found to raise dramatically plasma corticosterone levels in a dose-dependent manner. Plasma corticosterone time course for the 100 microgram/kg dose of nicotine produced an initial increase in corticosterone elevation which did not return towards control levels until after 30 min. The 200 and 500 microgram/kg doses, however, indicated a(More)
Daily IP injections of nicotine (200 micrograms/kg body weight) resulted in an adaptation of the nicotine induced rise in plasma corticosterone. By 30 days the plasma corticosterone rise was not significantly different from that seen in control animals receiving an injection of saline. A similar adaptation to the plasma corticosterone response to the stress(More)
The time course of plasma 11-hydroxysteroid elevation was studied in two stress situations: regular unsignalled foot shock which produces an intermediate steroid elevation and irregular signalled foot shock with the possibility of escape, which produces an extreme steroid elevation. The initial time course for steroid elevation followed a similar pattern(More)
A morphological and ultrastructural study is described which indicates that cellular activity in the adenohypophysis correlates well with the circulating levels of corticosterone. Intense secretory activity is observed in all tropic cells of the adenohypophysis over 10 days; thereafter the cellular morphology shows a return to the control condition. There(More)