J P Sinadinović

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BACKGROUND Galectin-3 is an endogenous beta-galactoside binding lectin with putative roles in development, immunomodulation, transformation and metastasis. The purpose of this study was to analyze galectin-3 expression in a series of human thyroid neoplastic lesions. METHODS A total of 76 cases, including 47 specimens of thyroid malignancies, 14(More)
Samples of thyroglobulin (Tg) were isolated from specimens of differentiated thyroid carcinoma of the papillary type and from normal adjacent glandular tissue, and the content of sialic acid was estimated. Also the in vitro incorporation of 14C-sialic acid, in the form of both CMP (cytidine 5'-monophospho-)--activated and non-activated N-acetyl-neuraminic(More)
In vitro lysosomal acid protease activity was studied in human papillary thyroid carcinoma (n = 13). As a control, morphologically normal thyroid tissue from the same patient was used in each individual case of carcinoma. Although a marked variation may be observed between individual cases, each examined papillary thyroid carcinoma showed significantly(More)
Thyroid auto-proteolytic activity in rats increased significantly only after several weeks of treatment with 1 mg iodide per day. Iodide added in vitro did not activate thyroid auto-proteolysis, nor was inhibition observed. Thyroid proteolytic activity was also tested using 131I-labelled heat-inactivated thyroid homogenate from control rats as substrate.(More)
The concentrations of T4, T3, r-T3, TSH and Tg were determined in parallel in maternal serum at the time of delivery and in cord blood. The serum T3 concentration in cord blood was significantly lower than that in the serum of the mother. However contrary to T3, r-T3 in cord serum was significantly higher than in maternal serum. Also, the level of TSH in(More)
Amiodarone is a benzofurane derivative which contains an appreciable amount of iodine (37%). It is used in cardiology as an antianginal and antiarrhythmic drug. Using guinea-pigs and rats as the animal model systems, the effects of amiodarone on normal and hyperplastic thyroid glands were investigated in eu- and hypothyroid animals. After the amiodarone(More)
Concentrations of thyroglobulin (Tg) in the sera of 48 euthyroid females of different ages suffering from diffuse and nodular goitre during TRH test, were determined. The aim of this study was to examine the correlation between the increased TSH levels and Tg, and thyroid hormones in the serum in dependence of pathomorphological thyroid status and the(More)