J P Mothet

Sort by:

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

Thomas Papouin, Laurent Ladépêche, +7 authors Stephane Oliet
Cell
2012

N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathological… (More)

Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

Aude Panatier, Dionysia T. Theodosis, +4 authors Stephane Oliet
Cell
2006

The NMDA receptor is a key player in excitatory transmission and synaptic plasticity in the central nervous system. Its activation requires the binding of both glutamate and a co-agonist like… (More)

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

J P Mothet, Angèle T Parent, +5 authors Solomon H Snyder
Proceedings of the National Academy of Sciences…
2000

Functional activity of N-methyl-D-aspartate (NMDA) receptors requires both glutamate binding and the binding of an endogenous coagonist that has been presumed to be glycine, although D-serine is a… (More)

Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine.

J P Mothet, Loredano Pollegioni, Gilles Ouanounou, Magalie Martineau, Philippe M. Fossier, Gérard Baux
Proceedings of the National Academy of Sciences…
2005

The gliotransmitter D-serine is released upon (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate and metabotropic glutamate receptor stimulation, but the mechanisms involved are… (More)

Purification of serine racemase: biosynthesis of the neuromodulator D-serine.

Herman Wolosker, Kevin N Sheth, +4 authors Solomon H Snyder
Proceedings of the National Academy of Sciences…
1999

High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine… (More)

pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.

Silvia Sacchi, Mariagrazia Bernasconi, +5 authors G. Molla
The Journal of biological chemistry
2008

Human genes coding for pLG72 and d-amino acid oxidase have recently been linked to the onset of schizophrenia. pLG72 was proposed as an activator of the human FAD-containing flavoprotein d-amino acid… (More)

D-serine signalling in the brain: friend and foe.

Magalie Martineau, Gérard Baux, J P Mothet
Trends in neurosciences
2006

Neurons and glia talk to each other at synapses. Glia sense the level of synaptic activity and consequently regulate its efficacy via the release of neuromodulators. One such glia-derived modulator… (More)

Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.

Magalie Martineau, Ting Shi, +7 authors J P Mothet
The Journal of neuroscience : the official…
2013

Glial cells are increasingly recognized as active players that profoundly influence neuronal synaptic transmission by specialized signaling pathways. In particular, astrocytes have been shown… (More)

Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.

Pascal Fossat, Fabrice R. Turpin, +8 authors J P Mothet
Cerebral cortex
2012

N-methyl-D-aspartate receptors (NMDARs) subserve numerous neurophysiological and neuropathological processes in the cerebral cortex. Their activation requires the binding of glutamate and also of a… (More)

Confocal imaging and tracking of the exocytotic routes for D-serine-mediated gliotransmission.

Magalie Martineau, Thierry Galli, Gérard Baux, J P Mothet
Glia
2008

D-Serine is an astrocyte-derived regulator for N-methyl-D-aspartate receptors, but the intracellular routes of its trafficking are still largely unknown. Here, we combined confocal microscopy with… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences