J P Dausse

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In rat cerebral cortex, the 3H-Nicergoline (an ergot alkaloid derivative) binding was rapid, reversible, saturable and of high affinity. In various structures of the central nervous system except midbrain and cerebellum, the maximum binding capacity (B max) for 3H-Nicergoline is greater that for 3H-Prazosin. The specificity studies of 3H-Nicergoline binding(More)
The alpha-adrenoceptor blocking properties of the two enantiomers of idazoxan have been investigated in rats, dogs and chicks, as well as their agonistic effects in pithed rats. At peripheral sites, (+) idazoxan was equipotent for blocking both postsynaptic alpha-1 and alpha-2 adrenoceptors of the rat and revealed to be a potent antagonist at presynaptic(More)
1. 3H-clonidine and the new antihypertensive drug, 3H-guanfacine (N-amino-2-[2,6-dichlorophenyl]-acetamide hydrochloride), bind with a high affinity to alpha 2-adrenoceptors in the rat central nervous system. 2. Dissociation curves for 3H-clonidine and 3H-guanfacine binding indicate the presence of high and low affinity binding sites. 3. In various rat(More)
[3H]Rauwolscine, a specific, potent, radiolabelled alpha 2-antagonist, binds to distinct high- and low-affinity alpha 2-adrenoceptors in crude membrane preparations of the rat cerebral cortex. The concentration of high-affinity alpha 2-adrenoceptors was increased by addition of sodium ions or guanylnucleotides. In synaptosomal plasma membrane preparations,(More)
Neonatal 6-hydroxydopamine treatment was used to destroy the noradrenergic nerve terminals in rat cerebral cortex and thus give some insight into the in vivo regulation of alpha-adrenoceptor subtypes, which in turn provides information concerning the anatomical localization of alpha 1- and alpha 2-adrenoceptors. Treatment of rats in the neonatal period with(More)
Neonatal 6-hydroxydopamine (6-OHDA) treatment was used to destroy the noradrenergic nerve endings in rat cerebral cortex and thus give some insight into the development and regulation of alpha-adrenoceptor subtypes, which in turn provides information concerning the anatomical localization of alpha 1- and alpha 2-adrenoceptors. In cerebral cortex of rats(More)
Surgical noradrenergic denervation of the cortex via frontal lobotomy was used to destroy the noradrenergic nerve endings and thus give some insight into the distribution of alpha-adrenoceptors. Frontal lobotomy caused a reduction in noradrenaline content in rat cerebral cortex (2.1 +/- 0.4 ng/mg protein for lesioned side, 6.0 +/- 0.3 mg/mg protein for(More)
1. 3H-prazosin binds to brain alpha 1-adrenoceptors with high affinity (K(D) 25 degrees C approximately or equal to 1 nM). The number of binding sites in different regions of the brain varied from 44-114 fmoles/mg of protein: striatum = medulla oblongata less than hypothalamus less than cortex. 2. 3H-p-aminoclonidine labels brain alpha 1-adrenoceptors. Its(More)
Prazosin is know to block postsynaptic alpha-adrenoceptors. In this study 3H-prazosin has been used to label biochemically central alpha-adrenoceptors. In rat brain membranes 3H-prazosin bound specifically in a rapid, reversible and saturable manner to a single class of high affinity sites. The relative order of potencies for inhibition of 3H-prazosin(More)
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