J P DaVanzo

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Male mice which are housed individually develop a characteristic aggressive, 'fighting' behavior. A small percentage of mice so isolated fail to become aggressive and in fact, behaviorally are strikingly different in that they develop a 'timid' behavior. Isolation-induced aggression is an androgen-dependent behavior and androgen-sensitive neurons have been(More)
1,1,3 Tricyano-2-amino-1-propene (Triap) is a small molecule that has neurotrophic properties similar to nerve growth factor (NGF). Studies have shown that NGF increases choline acetyltransferase (ChAT) activity, the enzyme responsible for the synthesis of acetylcholine, in several cell lines and in the CNS of adult animals. To investigate whether Triap can(More)
1,1,3 Tricyano-2-amino-1-propene (Triap) is a small molecular weight compound which increases the rate of nerve and tissue regeneration in several experimental systems. Early experiments with this compound showed that, like nerve growth factor (NGF), Triap induced neurite formation in chick spinal ganglia. To assess the similarity between NGF and Triap, we(More)
Mouse killing by rats represents a predatory behavior that can be modified by drugs from several different therapeutic classes and by environmental conditions. Buspirone and gepirone, non-benzodiazepine anxiolytics that stimulate serotonergic receptors (5HT1a) and inhibit isolation-induced intraspecies aggression, were tested for inhibition of muricidal(More)
The influence of environment (isolation) on GABA receptor numbers ( [3H]-muscimol binding sites) and affinities was investigated in specific limbic areas known to be involved with the development of muricide. Olfactory bulbs of isolated rats were found to have identical numbers of [3H]-muscimol binding sites whether or not they were muricidal. However, in(More)
Two classical tricyclic antidepressants possessing anticholinergic side effects, amitriptyline and desipramine, were compared to newer antidepressants lacking such activity, mianserin, trazodone, and bupropion, for their ability to inhibit muricidal behavior. As has been previously shown for the tricyclic antidepressants, the newer antidepressants without(More)
Eleven Dublin ICR mice sustaining nearly complete bilateral aspiration lesions of the olfactory bulbs were compared to 16 sham-operated mice on the frequency of agonistic, locomotory, social, and maintenance behaviors. The animals were housed in aggregate with two cages of bulbectomized mice and two cages of shams. A time sampling technique was used to(More)
The histofluorescent identification of indoleamine (serotonin)-concentrating neurons and the changes induced by olfactory bulbectomy (Obx) were correlated with reflexive biting and locomotor behavioral activities in grouped male mice. Between 2 and 35 days post-Obx, an increase in the number and fluorescent-intensity of indoleamine-containing neurons was(More)
Isolation-induced aggressive mice receiving total bilateral bulbectomy failed to fight after chronic training. Animals receiving sub-total olfactory bulbectomy were capable of being trained to attack but the latency to attack was increased. When mice were bulbectomized before being isolated they were incapable of attack regardless of training or(More)
Flutamide (FTA), an anti-androgenic compound, inhibited the effects of methyltestosterone (MT) on the weight of the ventral prostate, seminal vesicles and levator ani in male castrate mice. Castration prevented the development of aggressive behavior in mice isolated for 3 weeks. While chronic administration of MT to castrate isolated mice returned the(More)