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  • Yoshinori Fukui, Takashi Oono, +10 authors Takehiko Sasazuki
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 5 December 2000
  • T cell differentiation in the thymus is driven by positive selection through the interaction of alphabeta T cell receptors (TCRs) with self-peptides bound to self-major histocompatibility complexContinue Reading
    The induction of T-cell tolerance to self-antigens has been extensively characterized for immunodominant (ID) regions. However, tolerance toward other minor self-determinants has received lessContinue Reading
    We have analyzed the reactivity of a mouse monoclonal antibody directed against the human T cell receptor for antigen (TCR). This antibody (111-427) of immunoglobulin G1 isotype has been produced inContinue Reading