J. P. Briggs

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Experiments were performed in neuronal (nNOS)- and endothelial nitric oxide synthase (eNOS)-deficient mice to study the role of nitric oxide (NO) in macula densa control of renin secretion in vivo and in the isolated, perfused mouse kidney. Acute and chronic administration of loop diuretics was used as a method to stimulate macula densa-mediated renin(More)
In the adult rodent kidney cortex, cyclooxygenase-2 (COX-2), NO synthase (NOS1), and renin synthesis change in parallel on alterations in distal tubular NaCl concentration, and their products in part may mutually determine synthesis and activity of these enzymes. Epithelial NO synthesis has been postulated to exert a stimulatory role on COX-2 expression.(More)
Integrins mediate cell– cell and cell– extracellular matrix interactions and play key roles in development. ␤ 6 integrin expression has been demonstrated in human fetal kidney at a higher level than in the adult, making ␤ 6 integrin a marker of interest for the study of development of the nephron. The aims of this study were to determine the cDNA sequence(More)
We present a case study describing efforts to optimise and modernise " Modal " , the simulation and analysis pipeline used by the Planck satellite experiment for constraining general non-Gaussian models of the early universe via the bispectrum (or three-point correlator) of the cosmic microwave background radiation. We focus on one particular element of the(More)
The Howard Hughes Medical Institute (HHMI) recently announced a policy on Public Access to Publications for its investigators and Janelia Farm Research Campus scientists This policy requires our scientists to publish in only those journals that make original research articles and supplementary materials freely accessible through a public database within six(More)
To assess the feasibility of using the renin promoter for expressing Cre recombinase in juxtaglomerular (JG) cells only, we generated five independent transgenic mouse lines (designated hRen-Cre) expressing Cre recombinase under control of a 12.2-kb human renin promoter. In the kidneys of adult mice Cre mRNA (RT-PCR) was found in the renal cortex, with Cre(More)
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