J P Borkoski

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Bacterial lipopolysaccharide (LPS) suppresses feeding in rats when administered peripherally in the microgram range. In the present study, the effects of LPS (Escherichia coli serotype 0111:B4) on the central regulation of feeding in rats maintained ad lib was investigated. Intracerebroventricular (ICV) microinfusion of LPS (0.1 to 1000 ng/rat) suppressed(More)
Interleukin-1 beta (IL-1 beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) induce acute anorexia by direct action in the central nervous system (CNS) at estimated pathophysiological concentrations reported in the cerebrospinal fluid (CSF). Cytokine-induced anorexia may also participate in the long-term anorexia observed during disease. Here, we(More)
A variety of G-protein-coupled receptors are proposed to participate in the modulation of ingestive behavior and in the mode of action of antiobesity drugs. In the present study, we investigated the involvement of G-protein alpha-subunit subclasses (molecular transducers of multiple chemical signals) in the control of ingestive behavior. We report here that(More)
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