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A statistical model is added to the conventional physical model underlying factor analysis of medical image sequences (FAMIS). It allows a derivation of the optimal metric to be used for the orthogonal decomposition involved in FAMIS. The oblique analysis of FAMIS is extended to take this optimal metric into account. The case of scintigraphic image(More)
The aim of factor analysis of medical image sequences (FAMIS) is to estimate a limited number of physical or physiological fundamental functions. Its oblique rotation stage strongly affects the quality and the interpretation of the resulting estimates (factors and factor images). A new target apex-seeking method which integrates physical or physiological(More)
Factor analysis of dynamic structures (FADS) can automatically provide "physiological" factors related to anatomical structures that have different temporal behavior, even if these structures overlap; it also yields images corresponding to the factors' spatial distributions. In normal patients, two significant cardiac factors, corresponding to the atria and(More)
An international project was set up to study the clinical usefulness of intrarenal transit times derived from the renogram by deconvolution. A common data sheet, to collect clinical, biochemical, radiological and isotopic information, was completed by the centres. Five hundred and ninety-one patients were studied and the results analysed. The mean transit(More)
p. 1 Non-Rigid Motion Analysis in Medical Images: a Physically Based Approach p. 17 The Use of Active Shape Models for Locating Structures in Medical Images p. 33 Parameterized Feasible Boundaries in Gradient Vector Fields p. 48 Multi-Resolution Stochastic 3D Shape Models for Image Segmentation p. 62 Higher Order Differential Structure of Images p. 77(More)
A method based on factor analysis is presented to process dynamic volumetric (t + 3D) data sets acquired for flow, excretion, or metabolic studies. It estimates a reduced number of underlying physiological kinetics and their associated spatial distributions, corresponding to functional volumes, using dedicated algorithms. The global (t + 3D) approach is(More)
An increased number of image sequences is acquired in all modalities of the biomedical imaging field in order to study displacement or metabolism of a tracer or a contrast agent. It requires effective processing methods to estimate the underlying physiological components. We have developed a software package based on factor analysis algorithms which can(More)
A regional lung ventilation was modeled in five cases using Xe-127 during the first 3 min of wash-out. A factor analysis of the dynamic structures algorithm allowed estimation of the elementary kinetics and their respective proportions contained in time series images. Each factor was interpreted as the sampling of a compartment. It was associated to a(More)
The prognosis of localized osteogenic sarcoma (OS) has improved considerably since the introduction of neoadjuvant chemotherapy. However, there is a subset of patients who do not show full benefit from neoadjuvant chemotherapy because of chemoresistance. The early identification of poor responders to chemotherapy during neoadjuvant therapy remains(More)
A cocktail of three monoclonal F(ab')2 fragments against three distinct epitopes of calcitonin or PDN 21 was labelled with either 111In or 131I. These F(ab')2 fragments, a control 125I-F(ab')2 fragment and 99mTc-pertechnetate were injected into four patients suffering from medullary thyroid carcinoma. Scintigraphy data were processed by energy factor(More)