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A Dual Digital Signal Processing VME Board was developed for the Continuous Electron Beam Accelerator Facility (CEBAF) Beam Current Monitor (BCM) system at Jefferson Lab. It is a versatile general-purpose digital signal processing board using an open architecture, which allows for adaptation to various applications. The base design uses two independent(More)
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF). The B. pseudomallei flagellar protein FliC is strongly seroreactive and vaccination protects challenged mice. We assessed(More)
The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 µA. Recent burn-through simulations predict catastrophic beam line component failures below 1 µA of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an(More)
There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and Northern Australia. The imperative to identify vaccine targets is driven both by the public health agenda in these regions and biological(More)
Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins. Until recently, research into adaptive immunity targeting this bacterial pathogen has largely focused on the humoral response to these toxins. There is, however, growing(More)
Bacillus anthracis produces a binary toxin composed of protective antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). Most studies have concentrated on induction of toxin-specific antibodies as the correlate of protective immunity, in contrast to which understanding of cellular immunity to these toxins and its impact on infection(More)
A planned upgrade of the present 6 GeV CEBAF accelerator at Jefferson Lab will increase its energy to 12 GeV. To achieve this, new 7-cell superconducting cavities are being built to operate at an average accelerating gradient of 19.5 MV/m with and external Q of 2.2 x 10 7. The present RF system composed of an analog control loop driving 5 kW klystrons will(More)
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