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The human immunodeficiency virus (HIV) damages fronto-striatal regions, and is associated with deficits in executive functioning. We recently developed a semantic event sequencing task based on the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-III for use with functional magnetic resonance imaging (fMRI) and found recruitment of(More)
OBJECTIVE To investigate the integrity of hippocampal-prefrontal circuitry during episodic encoding in patients with HIV. METHODS Functional MRI was used to observe changes in blood oxygenation level-dependent (BOLD) signal in 14 HIV-positive participants and 14 age- and education-matched control subjects while performing an episodic encoding task.(More)
BACKGROUND Documented death and dysfunction of basal ganglia cells in patients seropositive for human immunodeficiency virus (HIV) suggest that the virus may cause structural compromise to these regions. OBJECTIVES To examine subcortical volumes in nondemented patients seropositive for HIV (HIV+) by means of a novel automated neuroanatomic morphometric(More)
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