J. Mike McHugh

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—Background subtraction is a powerful mechanism for detecting change in a sequence of images that finds many applications. The most successful background subtraction methods apply probabilistic models to background intensities evolving in time; nonparametric and mixture-of-Gaussians models are but two examples. The main difficulty in designing a robust(More)
The first purpose of this article is to examine general signaling transduction processes that become deranged in diabetes and the means by which they damage cells. However, among the cells that can be damaged by diabetes, the primary sensory neurons, also known as dorsal root ganglion (DRG) neurons, are uniquely sensitive. Damage to these cells results in(More)
We wrote a program that runs as a Microsoft Excel spreadsheet to calculate the diffusion of Ca2+ in a spherical cell in the presence of a fixed Ca2+ buffer and two diffusible Ca2+ buffers, one of which is considered to be a fluorescent Ca2+ indicator. We modeled Ca2+ diffusion during and after Ca2+ influx across the plasma membrane with parameters chosen to(More)
Most pain information begins at simple, naked nerve endings called nociceptors that form a functional pain unit with nearby tissue capillaries and mast cells. Tissue injury causes these nerve terminals to depolarize, an event that is propagated along the entire afferent fiber eventuating in sensory impulses reaching the spinal cord. This firing of primary(More)
Visual surveillance applications such as object identification, object tracking, and anomaly detection require reliable motion detection as an initial processing step. Such a detection is often accomplished by means of background subtraction which can be as simple as thresh-olding of intensity difference between movement-free background and current frame.(More)
We recorded Ca2+ current and intracellular Ca2+ ([Ca2+](i)) in isolated adult rat dorsal root ganglion (DRG) neurons at 20 and 30 degrees C. In neurons bathed in tetraethylammonium and dialyzed with cesium, warming reduced resting [Ca2+](i) from 87 to 49 nM and the time constant of the decay of [Ca2+](i) transients (tau(r)) from 1.3 to 0.99s (Q(10)=1.4).(More)
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