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A biomechanical energy harvester is presented that generates electricity during human walking. The key feature of this device is that the power generation adds only a minimal extra effort to the user. The knee-mounted devices accomplish this by selectively engaging power generation at the end of the swing phase when knee flexor muscles act to brake knee(More)
Human tumor xenograft studies are the primary means to evaluate the biological activity of anticancer agents in late-stage preclinical drug discovery. The variability in the growth rate of human tumors established in mice and the small sample sizes make rigorous statistical analysis critical. The most commonly used summary of antitumor activity for these(More)
In non-clinical studies, the proteasome inhibitor ixazomib inhibits cell growth in a broad panel of solid tumor cell lines in vitro. In contrast, antitumor activity in xenograft tumors is model-dependent, with some solid tumors showing no response to ixazomib. In this study we examined factors responsible for ixazomib sensitivity or resistance using mouse(More)
It has been detected that immunological activation induces stress-like behavioural and neurochemical changes in organs of animals and humans (1-6). Proinflammatory cytokines along with other compounds such as corticotropin releasing hormone (CRH) are clearly involved in the pathogenesis of stress (7-10). Activation of cytokine receptors and alterations in(More)