J. Matthijs Biesbroek

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OBJECTIVE To establish a fully automated, robust imaging marker for cerebral small vessel disease (SVD) and related cognitive impairment that is easy to implement, reflects disease burden, and is strongly associated with processing speed, the predominantly affected cognitive domain in SVD. METHODS We developed a novel magnetic resonance imaging marker(More)
BACKGROUND An acute subdural hematoma (aSDH) is a rare complication of aneurysmal subarachnoid hemorrhage (SAH) and is associated with poor clinical condition on admission and poor outcome. Risk factors for the development of an aSDH from aneurysmal rupture are unknown and may help our understanding of how an aSDH develops. OBJECTIVE To identify risk(More)
Semantic and phonemic fluency tasks are frequently used to test executive functioning, speed and attention, and access to the mental lexicon. In semantic fluency tasks, subjects are required to generate words belonging to a category (e.g., animals) within a limited time window, whereas in phonemic fluency tasks subjects have to generate words starting with(More)
BACKGROUND The aim of the current study was to determine the sensitivity and specificity of CT perfusion (CTP) for the detection of ischemic stroke by performing a systematic review and meta-analysis of published reports. METHODS We searched PubMed, Embase and the Cochrane library using the terms 'perfusion computed tomography', 'ischemic stroke' and(More)
INTRODUCTION Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional(More)
Lesion-symptom mapping is a valuable tool for exploring the relation between brain structure and function. In order to perform lesion-symptom mapping, lesion delineations made on different brain CT images need to be transformed to a standardized coordinate system. The preferred choice for this is the MNI152 template image that is based on T1-weighted MR(More)
BACKGROUND Acute subdural haematoma (aSDH) is a rare complication of aneurysmal subarachnoid haemorrhage (SAH) and is associated with poor clinical condition on admission and poor outcome. OBJECTIVE The aim of this study was to assess whether aneurysmal aSDH is an independent risk factor for poor outcome. METHODS In a series of 1632 patients retrieved(More)
Recognition memory, that is, the ability to judge whether an item has been previously encountered in a particular context, depends on two factors: discriminability and criterion setting. Discriminability draws on memory processes while criterion setting (i.e., the application of a threshold resulting in a yes/no response) is regarded as a process of(More)