J. Matthijs Biesbroek

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INTRODUCTION Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. METHODS Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional(More)
Semantic and phonemic fluency tasks are frequently used to test executive functioning, speed and attention, and access to the mental lexicon. In semantic fluency tasks, subjects are required to generate words belonging to a category (e.g., animals) within a limited time window, whereas in phonemic fluency tasks subjects have to generate words starting with(More)
Lesion-symptom mapping is a valuable tool for exploring the relation between brain structure and function. In order to perform lesion-symptom mapping, lesion delineations made on different brain CT images need to be transformed to a standardized coordinate system. The preferred choice for this is the MNI152 template image that is based on T1-weighted MR(More)
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