J. Maré Viles

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Myofiber degeneration which results from Sarcocystis infection exhibits a number of fine structural features suggestive of other myopathies and several well-defined fine structural features not characteristic of other myopathies. Some of these fine structural features are similar to those observed in intramuscular infections of Trichinella spiralis, another(More)
Intraventricular and intrahypothalamic infusions of phlorizin (PHL) are known to cause hyperphagia and to prevent gold thioglucose (GTG) lesion formation in the ventromedial hypothalamus (VMH), respectively. In this study, PHL, administered IP in a large dose (900 mg/kg), completely inhibited GTG necrosis in the VMH. PHL did not cause excessive urinary(More)
The effect of the glucose analogs 2-deoxyglucose (2DG), glucosamine (GLA), mannoheptulose (MAN), and gold thioglucose (GTG) on glucose utilization in the mouse ventromedial hypothalamus (VMH) was assessed by using an in vitro incubation system. The amount of 14C-CO2 generated from uniformly labelled 14C-glucose was measured in VMH tissue cubes. MAN and GTG(More)
Electron microscope studies of the cyst wall of a murine Sarcocystis-like organism of Mus musculus indicate that the sarcocyst wall is a degenerate muscle cell. The degenerate muscle cell contains nuclei, mitochondria, ribosomes, and myofibrils in disarray with the Z-bands thickened. Surrounding the outside of the muscle cell there is a layer of fibrous(More)
Mongolian gerbils do not develop ventromedial hypothalamic (VMH) lesions, as seen in mice, when challenged with gold thioglucose (GTG, 800, 1600 and 3600 mg/kg IP). Insulin administration or bilateral adrenalectomy, procedures which sensitize nonresponsive mice to GTG, have no effect in the gerbil given GTG. These findings suggest that the gerbil VMH(More)
In an ultrastructural study of gold thioglucose (GTG) lesion formation in the mouse ventromedial hypothalamus (VMH), a single intraperitoneal subnecrotic dose of GTG (100 mg/kg) was used to induce a VMH microlesion, visible only by electron microscopy. Definitive neuronal alterations were not evident until eight hours after GTG injection. Large(More)
Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 mM cis-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ultrastructure and fatty acid composition.(More)
Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 rrtM c/'s-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ultrastructure and fatty acid(More)