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The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurospheres, we document that prion infection is associated with(More)
AIMS To define regions of loss on the distal portion of chromosome 12q in gastric adenocarcinoma. METHODS Microsatellite analysis on chromosome 12 was performed on 19 human gastric cancer cell lines using 77 markers, 71 of which were within or distal to 12q21; some portions of this region showed extended regions of homozygosity (ERHs) in 10 of 19 gastric(More)
The aim of this work was to elucidate the molecular and biochemical mechanisms that control L-ascorbic acid (AsA) content variation in Myrciaria dubia. The AsA was quantified by high-performance liquid chromatography, gene expression by real-time quantitative PCR, and enzyme activities by spectrophotometric methods from leaves and immature fruits of two(More)
GRALPLA is a specification language based on algebraic specification [Berg89]. This language has been developed in the University of Granada for the study of interactive graphic system. One of the key points of this language is the support for rapid prototyping. It has a tool to checks the structure and specifications completeness, and if it is correct, to(More)
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