J. -M. Tiercy

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In transplantation of hematopoietic stem cells (HSCs) from unrelated donors a high HLA compatibility level decreases the risk of acute graft-versus-host disease and mortality. The diversity of the HLA system at the allelic and haplotypic level and the heterogeneity of HLA typing data of the registered donors render the search process a complex task. This(More)
Incompatibilities detected by the cytotoxic T-lymphocyte precursor frequency test [(CTLpf) (Rufer et al. 1993)] in serologically matched unrelated bone marrow donor/recipient pairs are usually caused by HLA subtypes (Bodmer et al. 1994) that escape detection by our routine tissue typing procedures. Here we present the case of a patient for whom three of six(More)
HLA-DRB1 is the most polymorphic locus of the HLA ctass II region, with 122 alleles identified so far (Bodmer et al. 1995; S. Marsh, personal communication). Sequencing data of the last few years have shown that most of the serological DR specificities are subdivided into numerous allelic subtypes that are functionally relevant for immune responses involved(More)
Small nuclear RNAs (snRNAs) from quiescent and serum-stimulated 3T3 cultures, labeled with [3H]uridine ([3H]U), were electrophoresed in polyacrylamide-urea slab gels and revealed by staining with ethidium bromide and by fluorography, Judged by labeling with [3H]U, synthesis of 7S and U1-U6 RNAs was very low or absent in quiescent cultures. The serum-induced(More)
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