J.-M. Tiercy

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In transplantation of hematopoietic stem cells (HSCs) from unrelated donors a high HLA compatibility level decreases the risk of acute graft-versus-host disease and mortality. The diversity of the HLA system at the allelic and haplotypic level and the heterogeneity of HLA typing data of the registered donors render the search process a complex task. This(More)
HLA-DRB1 is the most polymorphic locus of the HLA ctass II region, with 122 alleles identified so far (Bodmer et al. 1995; S. Marsh, personal communication). Sequencing data of the last few years have shown that most of the serological DR specificities are subdivided into numerous allelic subtypes that are functionally relevant for immune responses involved(More)
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