J. M. Santos

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Muscle contraction acutely increases glucose transport in both healthy and type 2 diabetic individuals. Since glucose uptake during muscle contraction has been observed in the absence of insulin, the existence of an insulin-independent pathway has been suggested to explain this phenomenon. However, the exact mechanism behind the translocation of GLUT4(More)
Mutations in the Jumonji AT-rich interactive domain 1C (JARID1C/SMCX/KDM5C) gene, located at Xp11.22, are emerging as frequent causes of X-linked intellectual disability (XLID). KDM5C encodes for a member of an ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in(More)
Contraction and insulin increase glucose uptake in skeletal muscle. While the insulin pathway, better characterized, requires activation of phosphoinositide 3-kinase (PI3K) and atypical protein kinase (aPKC), muscle contraction seems to share insulin-activated components to increase glucose uptake. This study aimed to investigate the interrelation between(More)
In mammals, the most important synchronizer for endogenous rhythms is the environmental light/dark cycle. In this report we have explored the ability of light/dark cycle and melatonin, the pineal hormone released during the night, to modulate cerebellar cholinergic input by interfering with the nicotinic acetylcholine receptors' (nAChRs) availability.(More)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have emerged as a potential common cause for both sporadic and familial Parkinson's Disease (PD) in different populations. The pleomorphic features exhibited by LRRK2 mutation carriers and the central role of Lrrk2 protein in the proper functioning of central nervous system suggest that mutations in(More)
User modeling and user adaptive interaction has become a central research issue to understand users as they interact with technology. The importance of the development of well adapted interfaces to several kinds of users and the differences that characterize them is the basis of the successful interaction. User Personas is a technique that allows the(More)
Current manufacturing scheduling has still difficulties to deal with real-world situations and, hence, human intervention is required to maintain real-time adaptation and optimization, to efficiently adapt to the inherent complex system dynamics. In this paper the prototype of an Adaptive Decision Support System for Interactive Scheduling with MetaCognition(More)
Contemporary manufacturing scheduling has still limitations in real-world environments where disturbances on working conditions could occur over time. Therefore, human intervention is required to maintain real-time adaptation and optimization and efficiently adapt to the inherent dynamic of markets. This paper addresses the problem of incorporating rush(More)
Alzheimer’s (AD) and Parkinson’s diseases (PD) share clinical and pathological features, suggesting that they could have common pathogenic mechanisms, as well as overlapping genetic modifiers. Here, we performed a case–control study in a Brazilian population to clarify whether the risk of AD and PD might be influenced by shared polymorphisms at PICALM(More)