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The training dose was progressively reduced (faded) using rats in a drug discrimination task in order to determine whether the discriminative stimulus effects of phencyclidine HCI (PCP) were separable from its response rate effects. Rats were initially trained to discriminate PCP from saline in a two-lever food-reinforced operant discrimination procedure.(More)
The behavioral effects of carbon monoxide (CO) administered via IP injection were investigated in the mouse. Mice were trained to lever press under a fixed-ratio (FR) 100 schedule of water reinforcement. Thirty-min test sessions were conducted either immediately or 30 min following IP injections of air (100 ml/kg) or CO (7.5, 15, 30, 50 or 100 ml/kg). CO(More)
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