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Different approaches to the decomposition of a nonsingular totally positive matrix as a product of bidiagonal matrices are studied. Special attention is paid to the interpretation of the factorization in terms of the Neville elimination process of the matrix and in terms of corner cutting algorithms of Computer Aided Geometric Design. Conditions of(More)
BACKGROUND Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used to treat MDR-TB. METHODS AND FINDINGS Three recent systematic reviews were used to identify(More)
A determinantal identity, frequently used in the study of totally positive matrices, is extended, and then used to re-prove the well-known univariate knot insertion formula for B-splines. Also we introduce a class of matrices, intermediate between totally positive and strictly totally positive matrices. The determinantal identity is used to show any minor(More)
OBJECTIVE To compare the clinical, immunologic, and virologic outcomes of efavirenz (EFV)-based versus protease inhibitor (PI)-based highly active antiretroviral therapy (HAART) in severely immunosuppressed HIV-1-infected patients. DESIGN Retrospective observational cohort study. METHODS Responses were analyzed according to the intent-to-treat principle(More)
OBJECTIVES To assess the impact of HIV-related immunodeficiency and antiretroviral treatment on the occurrence and evolution of abnormal Papanicolaou tests. STUDY DESIGN Cohort of 485 HIV-infected women with a known date of infection, enrolled during May 1993-April 1998 in 23 centres (gynaecology, infectious disease or STD clinics, or drug treatment(More)
BACKGROUND To our knowledge, no randomized trials have evaluated whether prophylaxis against toxoplasmic encephalitis can be safely discontinued after the CD4+ T cell count increases in response to highly active antiretroviral therapy. METHODS We conducted a randomized, nonblinded, multicenter clinical trial of the discontinuation of primary or secondary(More)
BACKGROUND The incidence of anal cancer among HIV-infected patients is higher than that in other populations. Anal high-grade squamous intraepithelial lesions are considered precursors to invasive squamous-cell carcinomas and are strongly associated to high-risk human papillomavirus infection. OBJECTIVE The aim of this study is to determine the prevalence(More)
OBJECTIVE To determine prevalence and risk factors for hypertension and isolated office hypertension diagnosed by ambulatory blood pressure monitoring in HIV-infected patients. METHODS Cross-sectional study of 310 patients. A 24-hour ambulatory blood pressure monitoring procedure was performed on the nondominant arm in those patients showing office(More)
BACKGROUND Medical treatment for multidrug-resistant (MDR)-tuberculosis is complex, toxic, and associated with poor outcomes. Surgical lung resection may be used as an adjunct to medical therapy, with the intent of reducing bacterial burden and improving cure rates. We conducted an individual patient data metaanalysis to evaluate the effectiveness of(More)
BACKGROUND The unquestionable benefit of antiretroviral therapy in reducing the rate of mother-to-child transmission can be lessened by potential maternal or neonatal toxicity. OBJECTIVE To analyze obstetric and perinatal complications in a cohort of HIV-infected pregnant women and their relationship with maternal antiretroviral therapy. POPULATION One(More)