J M Gracyk

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To assess the esterase dependency of human neutrophil secretion of lysosomal enzyme, the influence of several aromatic amino acid esters on phorbol myristate acetate-induced release of lysozome was studied. This function was found to be esterase-dependent on the basis of the inhibitory influence of such esters. Of the esters tested, tryptophan octyl ester,(More)
We have investigated the mechanism of the nonspecific component of chemotactic deactivation of human neutrophils. This component of deactivation occurs on exposure of neutrophils to larger doses of cytotaxin and is expressed as depressed subsequent spontaneous migration and chemotaxis toward all cytotaxins tested. We demonstrate a possible mechanistic(More)
The antiinflammatory drug, phenylbutazone (PBZ), has been studied in terms of its influence on chemotactic deactivation of human neutrophils. When PBZ was present during the time of preincubation of cells with N-formyl-methionyl-phenylalanine (F-Met-Phe), loss of subsequent spontaneous mobility and chemotactic responsivity to F-Met-Phe did not occur. The(More)
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