J-M Devoisselle

Learn More
Indocyanine green (ICG) is a fluorescent dye that has been used for the imaging of retinal and choroidal vasculatures for more than 30 years. Its high molecular weight, specific metabolic features, and its infrared spectra make the specificity of the images obtained with this dye in ophthalmology. The focus of this paper is to review the basic properties of(More)
BACKGROUND AND OBJECTIVES The present study was undertaken to evaluate the feasibility of thermal damage assessment of blood vessels by using laser-induced release of liposome-encapsulated dye. STUDY DESIGN/MATERIALS AND METHODS Experiments were performed in a hamster skin flap model. Laser irradiation was achieved with a 300 microm fiber connected to a(More)
This study reinvestigates the spectral properties of ICG (Indocyanine green) in vivo, the role of quenching, and the possibility of an interaction of ICG with blood components and/or vessel walls. ICG quenching as a function of concentration was studied by spectrophotometry on whole blood samples from golden hamsters. Fluorescence ICG characteristics were(More)
BACKGROUND AND OBJECTIVE The present study was undertaken to evaluate the selective laser photocoagulation of blood vessels in a hamster skin flap model using a specific indocyanine green (ICG) formulation. STUDY DESIGN/MATERIALS AND METHODS Experiments were performed in a hamster skin flap model after injection of ICG in aqueous solution (ICGA), or after(More)
The aim of this study is to determine the feasibility of loading biologically active molecules into templated mesoporous silica (MCM 41). This material shows an important mesoporosity associated to hexagonally organized channels, a narrow pore size distribution and a large surface area. Ibuprofen was selected as a model molecule since it is a well(More)
This study evaluated the effectiveness of dual-wavelength ratio fluorescence imaging using a pH-dependent indicator (5,6-carboxyfluorescein, 5,6-CF) for in vivo pH mapping of tissue. A prototype version of a highly sensitive fluorescence imaging device consisting of a modified xenon lamp, an image-intensified camera and a digital image-processing system has(More)
BACKGROUND AND OBJECTIVE The objective of this in vivo study was to assess the possible use of temperature-sensitive liposomes as a new approach to monitor the temperature induced by a laser. STUDY DESIGN An in vivo/ex vivo study was performed in rat liver after i.v. injection of liposomes loaded with a fluorescent dye. MATERIALS AND METHODS(More)
The use of paramagnetic ion chelates to enhance contrast between pathologic and surrounding parenchyma is extensively documented in the magnetic resonance imaging (MRI) literature. Liposomes can be used to increase chelate concentration in the pathologic area, thereby enhancing the efficiency of paramagnetic compounds as contrast agents. Liposomes (50 +/-(More)
Quercetin is a plant flavonoid with strong antioxidant and antiinflammatory properties interesting for skin protection. However, its poor water solubility limits its penetration and so its efficiency on skin. For this purpose, quercetin lipid nanocapsules were formulated implementing phase inversion technique wherein several modifications were introduced to(More)