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BACKGROUND Curcumin, the active ingredient of turmeric (Curcuma longa), has a wide range of beneficial effects including anti-inflammation and analgesia. However, poor bioavailability of curcumin hinders its clinical application. To overcome this limitation, we modified the structure of curcumin and synthesized new derivatives with favourable(More)
BACKGROUND Recent evidence suggests cathelicidin LL-37 to be a growth factor for various human cancers such as lung cancer, ovarian cancer and breast cancer. However, the effect of LL-37 against malignant skin cancer has not been reported. OBJECTIVES To investigate whether the human cathelicidin LL-37 is involved in the carcinogenesis of various skin(More)
METHODS We investigated mortality in the Korean working population aged 20–64 using registered death data from 1993 to 1997 obtained from the Korean National Statistics Office (NSO). Occupation and educational level, as described by next of kin, is recorded and coded routinely. Denominators were derived from a 10% stratified random sample of the 1995(More)
A hydroxyapatite layer was formed on the surface of a Ti-based alloy by ion-beam-assisted deposition. The deposition methodology comprised of an electron beam vaporizing a pure hydroxyapatite target, while an Ar ion beam was focused on the metal substrate to assist deposition. All deposited layers were amorphous, regardless of the current level of the ion(More)
Phosphorylation of eukaryotic initiation factor-2 alpha (eIF2 alpha) is increased in Alzheimer's disease (AD) and this protein can be phosphorylated by several kinases, including double-stranded RNA-dependent protein kinase (PKR), PKR-like endoplasmic reticulum kinase (PERK), amino acids-regulated eIF2 alpha kinase (GCN2) and heme-regulated eIF2 alpha(More)
A66-year-old Koreanmanwas referred for colonic polypectomy. A colonoscopy performed at another hospital 1 week previously had revealed a large pedunculated polyp with an erythematous surface that was occupying almost the entire lumen in the mid-sigmoid colon (●" Fig.1). The polyp appeared hyperplastic, and no biopsywas performed. The patient was not taking(More)