J M Bowdler

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A multicentre randomised, double-blind, parallel group, general practice study was undertaken to investigate the efficacy and safety of aceclofenac (200 patients, 100 mg twice daily and placebo once daily) in comparison with diclofenac (197 patients, 50mg three times daily) in patients with osteoarthritis of the knee. The treatment period of twelve weeks(More)
The efficacy and safety of aceclofenac (100 mg bid), a new nonsteroidal anti-inflammatory/anti-rheumatic agent, were compared with those of naproxen (500 mg bid) in a multi-centre, twelve-week, randomized, double-blind, parallel-group clinical trial in outpatients with active osteoarthritis of the knee. 190 patients received aceclofenac, 184 naproxen. The(More)
It has been confirmed that 24 hours following a series of electroconvulsive shocks (ECS) given once daily for 10 days (ECS X 10) to rats there is an increase in GABA concentration in the corpus striatum. A similar change was seen after the ECS had been given to rats anaesthetised with halothane, or when 5 ECS were given spread out over 10 days, the rats(More)
1 Following administration to rats of an electroconvulsive shock (ECS) which resulted in a major tonic-clonic seizure, no changes in [3H]-diazepam binding characteristics were observed in cortex or hippocampus with either a well washed membrane preparation or a crude synaptosomal preparation. 2 No changes were observed in [3H]-diazepam binding in any other(More)
1 A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS-treated rats showed an elevated serum concentration 5 min(More)
The efficacy and tolerability of aceclofenac (100 mg bid; n = 109), a new non-steroidal anti-inflammatory agent, was compared to that of indomethacin (50 mg bid; n = 110) in a multi-centre, 12-week, randomized, double-blind clinical trial in patients with rheumatoid arthritis. The efficacy of aceclofenac, on the basis of several clinical features(More)
The uptake and release of [3H]noradrenaline and [3H]-5-hydroxytryptamine (5-HT) were studied in cerebral cortex slices from rats 30 min and 24 h after a single electroconvulsive shock (ECS) and 24 h after a series of five shocks given over 10 days. Both the Km and Vmax for 5-HT uptake were lower than controls 24 h after a single ECS, whereas after 5 ECS(More)
Administration of bicuculline (3.5 mg/kg i.p.) or pentylenetetrazol (30 mg/kg i.p.) 3 min before each of a series of 5 electroconvulsive shocks (ECS), given over 10 days (1, 3, 5, 8 and 10), prevented the enhanced behavioural responses to the dopamine agonist apomorphine and the 5-hydroxytryptamine agonist quipazine 24 hr after the last application of ECS.(More)
Clonidine administration at low dose produces hypoactivity in both rats and mice, probably by stimulation of presynaptic alpha 2-adrenoceptors in the brain. This behaviour is antagonised by yohimbine pretreatment but is unaffected by pretreatment with prazosin. An electroconvulsive shock (ECS) given once daily for 10 days markedly attenuated the(More)
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