J Le Van Thoi

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Minimal inhibitory concentrations (MICs) of ofloxacin were evaluated by agar dilution for 1508 bacterial strains isolated in five hospitals. For Enterobacteriaceae sensitive to nalidixic acid, MICs ranged from 0.008 to 1 microgram/ml (mode MIC: 0.12); the different species of Enterobacteriaceae exhibited similar mode MICs (0.12) with the exception of E.(More)
The human pharmacology of ceftriaxone was studied in five healthy adult subjects receiving a 500 mg dose intravenously. Evolution of serum levels represents a two compartment open model; the distribution volumes, central and peripheric, were low (about 3 L); the elimination half-life was particularly long : 7.87 hours; the renal and serum clearances and(More)
This work reports a multicenter study of antibacterial activity of rosoxacin, a new antibacterial agent of the quinolone group. Enterobacteriaceae are very sensitive to rosoxacin (modal MIC 0,5 micrograms/ml); resistant strains are observed in all species, but more often among Serratia and Citrobacter. Pseudomonas aeruginosa is less sensitive with a maximum(More)
This work reports a multicenter study of antibacterial activity of cefatiolene (RP 42 980), a new third generation cephalosporin, in comparison with cefotaxime and lamoxactam. On the basis of MIC, activity of the three products is similar or Gram negative rods, but cefotaxime is a little more active on Enterobacteriaceae. The activity against Staphylococci(More)
This work reports a multicenter study of antibacterial activity of ceftazidime, a new third generation cephalosporin, on hospital Gram negative rods. Enterobacteriaceae are very sensitive to ceftazidime with a maximum number of strains inhibited by 1 microgram/ml or less (modal MIC 0, 125 microgram/ml); some resistant strains are observed, particularly(More)
All strains of Staphylococcus aureus and Gram negative bacilli (Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter) isolated from 01.01 to 03.31.83 were studied using agar diffusion with augmentin-impregnated discs (amoxicillin 20 micrograms + clavulanic acid 10 micrograms). Augmentin is active against penicillinase-producing Staphylococci(More)
In vitro antibacterial activity of 5 quinolones: nalidixic acid (NAL), pefloxacin (PEF), norfloxacin (NOR), ofloxacin (OFL) and ciprofloxacin (CIP) was evaluated by agar diffusion (disks Diagnostics Pasteur) for 1,253 bacterial strains (767 Enterobacteriaceae: E 164 P. aeruginosa: PA, 90 A. baumannii: AB and 232 S. aureus: SA) isolated during the last three(More)
Minimal inhibitory concentrations (MIC) of rokitamycin (R) were evaluated by agar dilution for 914 bacterial strain isolated in 4 hospitals and classed as a function of susceptibility and resistance to Macrolides-Lincosamides-Streptogramines group (MLS). MICs of R ranged from 0.06 to 1 microgram/ml (mode MIC 0.25-0.5) on Staphylococci susceptible to MLS and(More)
Minimal inhibitory concentrations (MICs) of imipenem were evaluated by agar dilution for 2 895 bacterial strains isolated in 9 hospitals. Imipenem proved highly active against Enterobacteriaceae, with an MIC less than or equal to 0.25 for 63% of the 1 556 tested strains, less than or equal to 1 for 89.6% and less than or equal to 4 for 99%. The different(More)
Minimal inhibitory concentrations (MICs) of ceftriaxone were determined by agar dilution for 2 099 strains isolated in six teaching hospitals. MICs were less than 1 microgram/ml for the great majority of Enterobacteriaceae, with mode MICs varying across groups from less than 0.008 micrograms/ml for Proteus (mirabilis and indole-positive) to 0.25 for(More)