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The disposition of monodesethylamodiaquine was studied in four healthy subjects after a single oral dose of 10 mg/kg amodiaquine base. Amodiaquine was not found in any sample, but the major metabolite monodesethylamodiaquine was detected and was assumed to be the sole derivative that contributed significantly to antimalarial activity in the blood. The best(More)
The plasma concentrations of the enantiomers of halofantrine and its N-desbutyl metabolite in six patients with malaria were measured after oral administration of 3×750 mg doses of micronised, racemic halofantrine hydrochloride given at 6-hour intervals. Significant differences were observed between the plasma concentrations of the enantiomers both of(More)
Plasmodiumfalciparum is the only human malaria parasite that can be maintained in continuous in vitro culture (Haynes et al. 1976; Trager and Jensen 1976). Attempts to establish a continuous in vitro culture system for P. vivax have thus far been unsuccessful (Lanners 1992). There is no report on the in vitro culture of P. ovale or P. malariae in the(More)
The efficient enforcement of fishing quotas and the repression of illegal fishing activities within the French and Australian exclusive economic zones represent a significant challenge to maritime authorities due to the size and remoteness of the area. A solution to this problem has been implemented by CLS through the installation of a SAR receiving station(More)
Congenital malaria (CM) has been considered to be rare, even in malaria-endemic areas but the disease can result in significant neonatal morbidity. Because of its rarity, the disease may go undiagnosed for a prolonged period in a seriously ill infant. We report the first case of Plasmodium malariae CM from a HIV mother. HIV could have facilitated the(More)
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