J. Lassen

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BACKGROUND On 20-21 February 2006, six cases of diarrhoea-associated haemolytic uraemic syndrome (HUS) were reported by paediatricians to the Norwegian Institute of Public Health. We initiated an investigation to identify the etiologic agent and determine the source of the outbreak in order to implement control measures. METHODS A case was defined as a(More)
Tesofensine (TE) is a novel triple monoamine re-uptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine, norepinephrine, and serotonin. In recent preclinical and clinical evaluations TE showed a robust anti-obesity effect, but the specific mechanism of this triple monoamine re-uptake(More)
BACKGROUND In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contamination possible, in order to prevent(More)
1-Tryptophan was administered to rats pretreated with selective inhibitors of the A and B forms of MAO deprenyl, a selective inhibitor of MAO-B, produced minor changes in behaviour and in the concentrations of apparent 5-HT and 5-HAA in brain. High doses of clorgyline, a selective inhibitor MAO-A, produced a characteristic stereotyped syndrome of(More)
A modified water-lick conflict paradigm is described, using trained rats for up to 35 weekly test sessions under 48 h of water deprivation. The rats rapidly became maximally suppressed by the punishment. This suppression was attenuated by the anxiolytics lorazepam, diazepam, phenobarbital, and meprobamate. The potentially anxiolytic drug CL 218872 and the(More)
Two different forms of hypermotility produced by the amphetamine derivatives PCA and H 77/77, 5 mg/kg of each, was studied in rats treated s.c. with the new 5-HT uptake inhibitor paroxetine. The substance inhibited the effect of PCA but did not influence that of H 77/77. The 5-HT-uptake inhibitors paroxetine, imipramine, and chlorimipramine were also(More)
The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the(More)
Rats were kept on a 12-h light-dark cycle. One hour after the light was switched on, physiological saline, (+)-amphetamine 1 mg/kg, and H 77/77 5 mg/kg were injected s.c.; the number of groomings was counted 1-2 h after the treatments. (+)-Amphetamine and H 77/77 produced increased grooming which was antagonized by the tyrosine hydroxylase inhibitor H 44/68(More)