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To elucidate the mechanisms responsible for the resistance of continuous cell lines to anoxic injury, we have compared the effects of ATP depletion induced by chemical anoxia on primary cultures of mouse proximal tubular (MPT) cells and on Madin-Darby canine kidney (MDCK) cells. Inhibition of ATP production by cyanide and 2-deoxyglucose (CN+DOG) in the(More)
Unmodified stroma free hemoglobin (SFH) increased renal vascular resistance (RVR) from 4.0 +/- 0.2 to 6.9 +/- 0.9 mmHg/ml/min in control isolated kidneys. In kidneys obtained from rats pretreated with the thromboxane synthetase inhibitor OKY-046 RVR increased from 3.9 +/- 0.3 to 4.8 +/- 0.4 mmHg/ml/min. The percent increase in RVR was greater in response to(More)
19-nor-deoxycorticosterone (19-nor-DOC) is a potent salt retaining and hypertensinogenic mineralocorticoid that is excreted in the urine. While the precursor of 19-nor-DOC, 19-oxo-DOC, is produced by the adrenal cortex, conversion to 19-nor-DOC does not occur in the adrenal gland. We have examined the hypothesis that 19-nor-DOC is synthesized from(More)
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