J. L. Hughes

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BACKGROUND Post-stroke microglial activation (MA) may have both neurotoxic and pro-repair effects, particularly in the salvaged penumbra. Mapping MA in vivo is therefore an important goal. 11C-PK11195, a ligand for the 18 kDa translocator protein, is the reference radioligand for MA imaging, but a correlation between the regional distributions of in vivo(More)
In acute stroke, the target of therapy is the severely hypoxic but salvageable tissue. Previous human studies using 18F-fluoromisonidazole and positron emission tomography (18F-FMISO PET) have shown high tracer retention indicative of tissue hypoxia, which had normalized at repeat scan >48 h later. In the only validation study of 18F-FMISO, using ex vivo(More)
Rescuing the ischemic penumbra from infarction is the mainstay of acute stroke therapy. However, the rescued penumbra may be affected by selective neuronal loss (SNL) and microglial activation (MA), which may hinder functional recovery and hence represent potential new therapeutic targets. Imaging them in vivo is currently attracting considerable interest,(More)
The advent of interactive computer systems and cathode ray tube terminals promises great achievements in the area of managerial decision-making. Thus far, however, graphic terminals and light pens have been used mostly to solve scientific, engineering, and mathematical problems. They have been applied relatively little to the types of problems frequently(More)
The occupancy by lorazepam of the benzodiazepine binding site of rat brain GABA(A) receptors was compared when measured using either in vivo binding of [(3)H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) in terminal studies or [(11)C]flumazenil binding in anesthetized animals assessed(More)
ADEPT (<italic>A</italic> <italic>D</italic>isplay-<italic>E</italic>xpedited <italic>P</italic>rocessing and <italic>T</italic>utorial) system is described. This system was designed to improve man-computer communications by employing a display unit to interleave tutoring with other computer operations such as simulation, programming, and information(More)
The occupancy by lorazepam of the benzodiazepine binding site of rat brain GABAA receptors was compared when measured using either in vivo binding of [H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) in terminal studies or [C]flumazenil binding in anesthetized animals assessed using a(More)
BACKGROUND The prevalence of rotator cuff repair continues to rise, with a noted transition from open to arthroscopic techniques in recent years. One reported advantage of arthroscopic repair is a lower infection rate. However, to date, the infection rates of these 2 techniques have not been directly compared with large samples at a single institution with(More)
A teaching system model that was incorporated into an operating system of a large computer is described. The model transferred control to the operating system to execute functions other than teaching, and then recovered control in order to resume teaching. The teaching system (ABAC-II) was written to run under the operating system (IBSYS) for the IBM 7044(More)
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