J Léonardelli

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It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its specific long lasting antagonist, the SR(More)
Arachidonyl ethanolamide, anandamide (ANA) was administered to male rats via a single i.p. injection at a dose of 0.02 mg/kg. In an parallel experiment ANA injection was preceded by the injection of SR 141716 (1.0 mg/kg), a selective and potent cannabinoid receptor antagonist. We observed using FOS protein immunocytochemistry that the parvocellular part of(More)
The distribution of supraependymal nerve fibers (SEF) containing serotonin (5-HT) was investigated immunohistochemically in the forebrain of the guinea pig. The highest densities of immunoreactive axons were found in the pars centralis and the inferior horn of the lateral ventricle and also in the superior part of the third ventricle. Because of the special(More)
We have reported earlier that delta 9-tetrahydrocannabinol (THC) if injected over the 3rd week of pregnancy with a daily dose of 1 micrograms/kg b.wt., caused a significant prolongation of pregnancy and 42% of stillbirths, although no teratological effects were observed. In the present study, we investigated the postnatal development of(More)
Because of the presence of an enkephalin-related substance in the somatostatin terminals of the median eminence, an investigation was carried out on the staining for enkephalin of the somatostatin-containing perikarya localized in the hypothalamic periventricular nucleus. Only an occasional and weak enkephalin immunoreactivity was detected in these(More)
A peptide immunochemically related to beta-endorphin was detected in some LH-RH neurons of the fetal human hypothalamus by comparison of adjacent sections stained for beta-endorphin and for LH-RH. In the same section, by successive staining and after antibody elution, both peptides were again revealed in the same neuron. The significance of the presence of(More)
The antiovulatory effect of sulpiride is mediated via inhibition of the LH-RH release: when given during 10 days in guinea pigs, sulpiride is able to promote an increase of LH-RH immunoreactive substance in anterior hypothalamic and suprachiasmatic neurons. This storage probably related with inhibition of LH-RH release, is permitted by catecholamines, since(More)