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BACKGROUND Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown. HYPOTHESIS/OBJECTIVES Administration of pimobendan (0.4-0.6 mg/kg/d in divided doses) to dogs with increased heart size secondary to preclinical MMVD, not… (More)
A phytochemical study of the flowers of ARNICA CHAMISSONIS Less. subsp. FOLIOSA (Nutt.) Maguire (Asteraceae) has resulted in the identification of a further 23 helenanolides. Six of them, 2alpha-hydroxy-6- O-angelicoyl-2,3-dihydrohelenalin ( 3B), 2alpha-hydroxy-6- O-senecioyl-2, 3-dihydrohelenalin ( 3C), 2alpha-hydroxy-6-… (More)
The flowers of ARNICA CHAMISSONIS ssp. GENUINA afforded in addition to 8 helenanolides ivalin, the first eudesmanolide found in the genus ARNICA.
From the flowers of Arnica chamissonis Less, sub-sp. foliosa (Nutt.) Maguire and its variety incana (Gray) Hulten two new naturally occuring pseudoguaianolides were isolated and their structures established by spectroscopic methods. They are shown to be 4-O-acetyl-6-desoxychamissonolide ( 3) and the propionylic ester of 11,13-dihydrohelenalin which was… (More)