J. Keith Dewyngaert

Learn More
PURPOSE High-grade glioma treatment includes ionizing radiation therapy. The high invasiveness of glioma cells precludes their eradication and is responsible for the dismal prognosis. Recently, we reported the down-regulation of MHC class I (MHC-I) products in invading tumor cells in human and mouse GL261 gliomas. Here, we tested the hypothesis that(More)
Purpose: To determine whether inhibition of TGFb signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. Experimental Design: TGFb-mediated growth and Smad phosphorylation of MCF7, Hs578T, MDA-MB-231, and T47D human breast cancer cell lines were examined and correlated with clonogenic survival following graded radiation(More)
they have been initiated by a psychiatrist. " Aripiprazole and quetiapine are both approved by the US Food and Drug Administration for augmentation pharmacotherapy of major depressive disorder. Given a shortage of psychiatrists, 5 and wait times of up to 3 months to see a psychiatrist, and in an age when psychiatric disorders are the leading source of(More)
PURPOSE Limited information is available comparing toxicity of accelerated radiotherapy (RT) to that of standard fractionation RT for early stage breast cancer. We report early and late toxicities of two prone regimens of accelerated intensity-modulated radiation therapy (IMRT) with a concomitant boost (CB) to the tumor bed delivered over 3 or 5 weeks as(More)
INTRODUCTION Evaluate use of novel multi-channel applicator (MC) Capri™ to improve vaginal disease coverage achievable by single-channel applicator (SC) and comparable to Syed plan simulation. MATERIALS AND METHODS Twenty-eight plans were evaluated from four patients with primary or recurrent gynecologic cancer in the vagina. Each received whole pelvis(More)
This project investigated reducing the artifact content of In-ill ProstaScint SPECT scans for use in treatment planning and management. Forty-one patients who had undergone CT or MRI scans and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans were included. SPECT volume sets, reconstructed using Ordered Set-Expectation Maximum (OS-EM) were compared(More)
Using program IRREG as a standard, we have compared speed and accuracy of several algorithms that calculate the scatter dose in an irregular field. All the algorithms, in some manner, decompose the irregular field into component triangles and obtain the scatter dose as the sum of the contributions from those triangles. Two of the algorithms replace each(More)
  • 1