J Kamura Fukushi

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Valosin-containing protein (VCP) has been shown to colocalize with abnormal protein aggregates, such as nuclear inclusions of Huntington disease and Machado-Joseph disease, Lewy bodies in Parkinson disease. Several mis-sense mutations in the human VCP gene have been identified in patients suffering inclusion body myopathy associated with Paget disease of(More)
VCP/p97 is a hexameric ring-shaped AAA(+) ATPase that participates in various ubiquitin-associated cellular functions. Mis-sense mutations in VCP gene are associated with the pathogenesis of two inherited diseases: inclusion body myopathy associated with Paget's disease of the bone and front-temporal dementia (IBMPFD) and familial amyotrophic lateral(More)
Abnormal protein accumulation is often observed in human neurodegenerative disorders such as polyglutamine diseases and Parkinson disease. Genetic and biochemical analyses indicate that valosin-containing protein (VCP) is a crucial molecule in the pathogenesis of human neurodegenerative disorders. We report here that VCP was specifically modified in(More)
+Okada, Y; Matsumoto, Y; Fukushi, J; Kamura,S;Fujiwara, T; Iida, K; Koga, M; +Oda, Y; Matsuura, S; +Yamada, H; +Ono, M; Iwamoto, Y. +Kyushu University School of Medicine, department of Orthopaedic Surgery, Fukuoka, Japan +Kyushu University School of Medicine, department of Anatomic Pathology, Fukuoka, Japan + Division of Host Defense, Medical Institute of(More)
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