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BACKGROUND AND THE PURPOSE OF THE STUDY Itraconazole is a poorly water soluble drug which results in its insufficient bioavailability. The purpose of the present study was to formulate Itraconazole in a nanosuspension to increase the aqueous solubility and to improve its formulation related parameters, dissolution and hence oral bioavailability. METHODS(More)
A controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. Using compritol 888 ATO (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. Pectin, a polysaccharide, was used as bacterial(More)
BACKGROUND AND THE PURPOSE OF THE STUDY The combination of angiotensin II receptor antagonists and HMG CoA reductase inhibitors have shown to confer renoprotection.The purpose of this study was to find out the renoprotective effects of telmisartan and atorvastatin in combination and in monotherapy of Streptozotocin (STZ) induced diabetic nephropathy in(More)
The present invention relates to produce multiple unit particle system (MUPS) of stabilized ramipril pellets, hydrochlorothiazide, diluents, superdisintegrants, and lubricants which produce better dissolution of the system for better bioavailability with improving stability and bioavailability of ramipril. More particularly, the present invention is(More)
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