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A method of obtaining rate equations from conductance-based equations is developed and applied to fast-spiking and bursting neocortical neurons. It involves splitting systems of conductance-based equations into fast and slow subsystems, and averaging the effects of fast terms that drive the slowly varying quantities by showing that their average is closely(More)
OBJECTIVES To clarify the clinical significance of increased signal intensities on T1 weighted magnetic resonance imaging (MRI) we performed a large-scale epidemiological study on asymptomatic manganese (Mn)-exposed workers with its focus on MRI. METHODS We randomly selected 121 male workers out of a total of 750 workers including Mn-exposed, non-exposed(More)
Epidermal growth factor and platelet-derived growth factor can stimulate the production of the second messenger inositol trisphosphate in responsive cells, but the biochemical pathway for these signaling events has been uncertain because the reactions have not been reconstituted with purified molecules in vitro. A reconstitution is described that requires(More)
It is difficult to distinguish manganism from idiopathic parkinsonism by clinical signs only. Case history and examination: A 48-year-old welder for over 10 years complained of masked face, right side (arm and leg) resting tremor, and bradykinesia for over one year. Magnetic resonance imaging (MRI) findings showed symmetrical high signal intensities in the(More)
To gain insight into the number of loci of large effect that underlie variation in cattle, a quantitative trait locus (QTL) scan for 14 economically important traits was performed in two commercial Angus populations using 390 microsatellites, 11 single nucleotide polymorphisms (SNPs) and one duplication loci. The first population comprised 1769 registered(More)
A physiologically-based corticothalamic neural field model is used to study slow wave oscillations including cortical UP and DOWN states in deep sleep by extending it to incorporate bursting dynamics of neurons in the thalamic reticular nucleus. The interplay of local bursting dynamics and network interactions produces the cortical UP and DOWN states of(More)
Cyclomaltodextrinase (CDase, EC, maltogenic amylase (EC 3. 2.1.133), and neopullulanase (EC are reported to be capable of hydrolyzing all or two of the following three types of substrates: cyclomaltodextrins (CDs); pullulan; and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4(More)
A compact physiologically based mean-field formulation of brain dynamics is proposed to model observed brain activity and electroencephalographic (EEG) signals. In contrast to existing formulations, which are more detailed and complicated, our model is described by a single second-order delay differential equation that encapsulates salient aspects of the(More)