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Thirty-eight patients with symptomatic recurrent primary or metastatic brain tumors were treated with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) at an initial dose of 120-130 mg/m2 with subsequent doses determined by the degree of delayed toxicity. The interval between treatments was usually 6 weeks. Two groups of patients were treated: those who(More)
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