J. J. Stragand

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The present studies were initiated to investigate the effectsof methylprednisolone (MP)on the growthand cell kinetics of C3H/HeJ spontaneousmammary tumor. MP given every 12 hr in 9 doses at 10 or 20 mg/kg/dose resulted In temporary stasis of tumor growth with liftle or novolumeregression.Cell kineticparameterswere deter minedbyIn vitromethodsafter MP every(More)
Two human colonic adenocarcinoma cell lines were propagated in the Rowett athymic rat. Line LoVo displayed a well-differentiated morphology and exhibited progressive growth over a 70-day observation period with a doubling time of 8.5 days throughout. No metastatic involvement was noted. Xenografts of SW 620 cells were undifferentiated and highly necrotic.(More)
The cytotoxic and stathomokinetic effects of vincristine (VCR) on murine fibrosarcoma (FSa) cells, grown either in vitro as primary cultures or in vivo as micro- or macroscopic pulmonary nodules, were determined and compared. FSa cells were separated and synchronized on the basis of size by centrifugal elutriation. Flow microfluorometry (FMF) was used to(More)
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